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Alcohol and Cancer Risk: Ethanol and Acetaldehyde

Alcohol is a classified Group 1 carcinogen linked to seven cancer types, including breast, colorectal, esophageal, and liver cancers.

Source

IARC Monographs Volume 100E: Personal Habits and Indoor Combustions (Consumption of Alcoholic Beverages)

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Key fact

Alcohol is classified as a Group 1 carcinogen and is linked to seven different cancer types.

The short answer

Alcohol is a classified Group 1 carcinogen linked to seven cancer types, including breast, colorectal, esophageal, and liver cancers.

  • Alcohol is classified as a Group 1 carcinogen and is linked to seven different cancer types.

  • Those types include breast, colorectal, esophageal and liver cancer.

  • Breaking alcohol down produces acetaldehyde, a toxin that damages DNA and stops cells repairing that damage.

Watch: Alcohol and cancer risk

59 sec · Captioned · Alcohol is a Group 1 carcinogen linked to seven cancers — the under-known risk.

Educational only — this video explains general report language and is not medical advice. Only your care team can say what a result means for you.

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The full explanation.

Alcohol and cancer risk: the science behind ethanol and acetaldehyde

Alcohol is a Group 1 carcinogen. That is the highest category the International Agency for Research on Cancer uses. It means the evidence that alcohol causes cancer in people is strong.

The World Health Organization says alcohol causes at least seven types of cancer. Those are cancers of the mouth, the throat (pharynx), the voice box (larynx), the esophagus, the liver, the colon and rectum, and the breast in women.

Why alcohol raises risk

Two chemicals matter. The first is ethanol, the alcohol in every kind of drink. The second is acetaldehyde, which your body makes when it breaks ethanol down. Both are carcinogenic. Acetaldehyde is a toxic chemical that can damage DNA and proteins.

An enzyme called ALDH2 normally turns acetaldehyde into harmless substances. Some people carry a gene variant that makes this enzyme work poorly. In them, acetaldehyde builds up, and drinking raises cancer risk more sharply.

Because it is the ethanol itself that does the harm, any alcoholic drink can raise risk. Beer, wine, and spirits are not different in this respect.

What this means for you

Drinking less lowers your exposure to both ethanol and acetaldehyde. Risk also depends on other things, including smoking, family history, and other health conditions. Your care team can talk through your own picture. If you are in treatment, ask whether alcohol interacts with your medicines.

Be careful with health claims you read online. Watch for red flags such as 'miracle cures', secret treatments, or supplements sold alongside the advice. Bring any add-on therapy or strict diet to your care team first, because some can interact with cancer drugs.

Questions to ask your care team

  1. Which cancer types are most strongly linked to alcohol?
  2. How does drinking less change my risk over time?
  3. Does alcohol interact with any medicine I take?

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Common questions

How does alcohol increase cancer risk?

When body tissues break down alcohol, it produces acetaldehyde, a chemical toxin that damages DNA and prevents cells from repairing the damage.

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Prepared by Cancer Explained's AI-assisted editorial system

Written from IARC Monographs Volume 100E: Personal Habits and Indoor Combustions (Consumption of Alcoholic Beverages) material and checked line by line against the source cited below.

Plain-language explanation of the published sources cited on this page. AI-assisted, source-checked, not clinician-reviewed.

Written by: Cancer ExplainedSources last checked: 2026-07-23 what this meansLast updated: 2026-08-11Next planned review: 2027-07-23

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Cancer Explained does not originate medical claims. Every page restates guidance already published by the National Cancer Institute, the CDC, the USPSTF and the FDA, in plain language, with the source cited so you can check the original yourself. AI does the translating and organizing; automated checks test claims, citations, clarity and safety before anything publishes. We do not employ clinicians and do not intend to — our work is translation and navigation, not clinical judgment. Nothing here is personal medical advice, and no page can account for your particular situation.

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Human medical review: not completed. Pages here are not signed off by a clinician before they publish. That is not an oversight we are quietly working around: we restate published guidance and cite it, so the authority belongs to the source rather than to us, and every page names where its claims come from — you can verify us instead of trusting us. Where a volunteer clinician has reviewed a page, their name and credentials appear on it; where no name appears, no clinician has checked it. We are glad to have reviewers and are recruiting them, and we do not hold pages back waiting for one. Use this site to understand your situation and to ask better questions of the people treating you.

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How this page was created

Cancer Explained does not originate medical claims. Every page restates guidance already published by the National Cancer Institute, the CDC, the USPSTF and the FDA, in plain language, with the source cited so you can check the original yourself. AI does the translating and organizing; automated checks test claims, citations, clarity and safety before anything publishes. We do not employ clinicians and do not intend to — our work is translation and navigation, not clinical judgment. Nothing here is personal medical advice, and no page can account for your particular situation.

Editorial status: Source checked This page was written with AI assistance and checked line by line against the sources listed on it. That confirms the sources support what the page says. It is not a medical review, and it does not confirm the page is complete or right for your situation.

Human medical review: not completed. Pages here are not signed off by a clinician before they publish. That is not an oversight we are quietly working around: we restate published guidance and cite it, so the authority belongs to the source rather than to us, and every page names where its claims come from — you can verify us instead of trusting us. Where a volunteer clinician has reviewed a page, their name and credentials appear on it; where no name appears, no clinician has checked it. We are glad to have reviewers and are recruiting them, and we do not hold pages back waiting for one. Use this site to understand your situation and to ask better questions of the people treating you.

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